From the time sildenafil was released as a medication for erectile dysfunction, it has proven for years and years its efficacy. Impotence has been a struggle especially for men who are old. It even results in interpersonal conflicts as well as mental health problems — which makes ED a bigger issue than it already is, And with Viagra, sildenafil’s brand name, a lot has overcome that dysfunction. With this, it is important for us, both males and females, to understand how it works. This is why we are going to break down piece by piece the history and the basic mechanism of sildenafil.
History of Sildenafil
Pfizer, a huge pharmaceutical company, discovered sildenafil in 1989 while studying phosphodiesterase type 5 or PDE5 inhibitors and their potential as a treatment to angina or heart-related chest pains. After a series of animal testing, results have shown that it is an effective medication for the disease. So, they proceeded to conduct their first clinical trial.
During the clinical trial, a nurse has noticed that the males who were participating were lying down on their stomachs after taking the medication. It was found out that the reason for this is that they got an erection and were embarrassed about it. This unexpected occurrence proved that sildenafil helps in increasing the blood flow in a human’s body, but what the doctors were not able to take into account beforehand is the area the medication is going to be affecting. Since then, sildenafil was developed to become a treatment for erectile dysfunction. And in March of 1998, its brand name Viagra was approved by the FDA as an oral ED medication and was released in the market.
How Sildenafil Works
Sildenafil belongs to the drug class called PDE5 inhibitors. PDE5 is a type of enzyme found inside our bodies and is known to destroy cyclic guanosine monophosphate or cGMP. A second molecule messenger, cGMP regulates different physiological processes that occur in the myocardium or the middle layer of the heart wall. These processes include vasodilation which is the widening of blood vessels that allow the increase of blood flow. Furthermore, GMP is also an important mechanism in the penile area that triggers an erection.
With sildenafil blocking PDE5 enzymes, it helps cGMP promote vasodilation in the blood vessels which results in the influx of blood flow and then helps with penile erection. This proves that sildenafil is an effective and safe medication for erectile dysfunction.
The standard oral dosage of sildenafil prescribed to a patient is 50mg. The physician may then increase or decrease the dosage depending on the tolerance of the patient. Remember that sildenafil must be prescribed by your doctor to make sure that you are not allergic to it or won’t show any side effects. For it to take effect, the drug must be taken 30 minutes before sexual intercourse and its efficacy can last between 4 to 6 hours. Sildenafil must not be taken more than once in 24 hours. If you want to buy from the UK, there are clinics that sell it online.
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